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Can kidney cancer be cured? Surgery is most common treatment for kidney cancer—most people with early stage cancer (stages 1, 2, and 3) can be cured with surgery. In a radical nephrectomy, the entire kidney is removed. If needed, the surrounding tissues and lymph nodes may also be removed. What are the first signs of kidney cancer? Symptoms Blood in your urine, which may appear pink, red or cola colored. Pain in your back or side that doesn't go away. Loss of appetite. Unexplained weight loss. Tiredness. Fever. Is Stage 4 kidney cancer curable? Stage 4 renal cancer may be treatable, but it has a low survival rate. Some patients opt for palliative treatments to help reduce symptoms and lengthen life.